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American Journal of Epidemiology Vol. 116, No. 6: 933-939
Copyright © 1982 by The Johns Hopkins University School of Hygiene and Public Health

research-article

TYPE-SPECIFIC IMMUNITY AND PHARYNGEAL ACQUISITION OF GROUP A STREPTOCOCCUS

NABIL GUIRGUIS1, DAVID W. FRASER2,, RICHARD R. FACKLAM2, AZIZ EL KHOLY1 and LEWIS W. WANNAMAKER3

1Biomedical Research Center for Infectious Diseases Cairo, Egypt
2Bacterial Diseases Division, Center for Infectious Diseases, CDC Atlanta, GA
3Dept of Pediatrics, University Medical School, U. of Minnesota Minneapolis, MN 55455

Send reprint requests to Dr David W. Fraser, Center for Infectious Diseases, CDC, Bldg 1, Room 5035, Atlanta, GA 30333

A prospective study of spread of M-type 1, 2, 13, 14, 25 and 60 group A Streptococcus In 64 families In Qalyub, Egypt, in 1972-1974 showed that type-specific serum bactericidal antibody does not protect against pharyngeal acquisition of homologous organisms. The presence of type-specific antibody also does not appear to affect duration of carriage of the organism. Type-specific Immunity must be mediated in another way, such as by local antibody or through prevention of infection (as evidenced by a host response) following acquisition. This study also confirms the observations of others that administration of penicillin lowers the probability that a person who acquires group A Streptococcus will develop type-specific antibody.

antibodies, bacterial; Immunity; Streptococcus


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