Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (19)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by NURMINEN, M.
Right arrow Articles by HERNBERG, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by NURMINEN, M.
Right arrow Articles by HERNBERG, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology Vol. 115, No. 1: 107-118
Copyright © 1982 by The Johns Hopkins University School of Hygiene and Public Health

research-article

QUANTITATED EFFECTS OF CARBON DISULFIDE EXPOSURE, ELEVATED BLOOD PRESSURE AND AGING ON CORONARY MORTALITY

MARKKU NURMINEN1,, PERTTI MUTANEN1, MATTI TOLONEN2 and SVEN HERNBERG1

1Dept. of Epidemiology and Biometry, Institute of Occupational Health Helsinki, Finland
2Uusimaa Regional Institute of Occupational Health Helsinki, Finland

Send reprint requests to Mr. Markku Nurminen, Dept. of Epidemiology, Institute of Occupational Health, Haartmaninkatu 1, SF-00290 Helsinki 29, Finland

Risk function analysis was performed in order to clarify the relationship between coronary heart disease death rate and occupational carbon disulfide exposure along with two other important risk factors, elevated diastolic blood pressure and older age, in a data set obtained from a 10-year prospective follow-up of coronary mortality in two cohorts of over 340 male industrial workers in Finland. The sole effect of carbon disulfide on the coronary mortality was statistically significant (relative risk = 2.3), and it was largely independent of the level of the other two risk factors. Log-linear models were fitted to predict coronary heart disease deaths. The analysis identified the dual role of raised blood pressure in the potential mechanism of coronary death. Relative risks ranging up to 48 were obtained for the joint non-synergistic effect of these three factors in the exposed group compared to a subgroup of nonexposed, 40-year-old normotensive men. The effect of carbon disulfide exposure on the risk of coronary death, while clearly distinguishable from the effect of hypertension and aging, stayed subordinate to them, but nevertheless remained an important risk element in the work environment.

coronary disease; models; theoretical; occupational diseases; risk; statistics


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Occup. Environ. Med.Home page
Y Nishiwaki, T Takebayashi, T O'Uchi, T Nomiyama, T Uemura, H Sakurai, and K Omae
Six year observational cohort study of the effect of carbon disulphide on brain MRI in rayon manufacturing workers
Occup. Environ. Med., March 1, 2004; 61(3): 225 - 232.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.