Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by NATTA, P. A. V.
Right arrow Articles by KWITEROVICH, P. O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by NATTA, P. A. V.
Right arrow Articles by KWITEROVICH, P. O., JR.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology Vol. 114, No. 3: 385-397
Copyright © 1981 by The Johns Hopkins University School of Hygiene and Public Health

research-article

THE EAST BALTIMORE STUDY

II. FAMILIAL AGGREGATION OF PLASMA LIPID LEVELS IN JUVENILES IN A BLACK INNER-CITY POPULATION

PEARL A. VAN NATTA1, JEFF A. JENKINS2, GARY A. CHASE3, KIT ALVARO2, PAUL S. BACHORIK2 and PETER O. KWITEROVICH, JR.2,

1Dept. of Epidemiology The Johns Hopkins U. School of Hygiene and Public Health,Baltimore, MD 21205
2Lipid Research Atherosclerosis Unit Depts. of Pediatrics and Medicine, The Johns Hopkins U. School of Medicine, Baltimore, MD 21205
3Dept. of Health Services Administration The Johns Hopkins U. School of Hygiene and Public Health, Baltimore, MD 21205

Reprint requests to Dr. Kwiterovich, Dept. of Pediatrics, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21205

Familial aggregation of plasma lipid levels among 676 black juveniles, aged less than 20 years and residing in 202 households in East Baltimore, Maryland, was assessed by the intraclass correlation coefficient of residuals from sex-specific cubic regressions on age. Significant aggregation of both plasma cholesterol (r = 0.23, p < 0.005) and plasma triglyceride (r = 0.27, p < 0.005) levels were found, in addition, no effect on familial aggregation was found for each of several measures of family structure: number of juvenile household members, closeness in age, all children over 9 years of age, or shared surname. Two methods of classifying juvenile household size were compared. An association between classification method and juvenile household size was demonstrated (p < 0.005) for the distributions of households and of children. The intraclass correlation coefficients for plasma cholesterol and plasma triglyceride for households classified by number of juveniles were higher than the coefficients for the households grouped by the number of juveniles admitted to the study, when compared for each classification number, 2 through 4. Evidence for an effect on familial aggregation of the socioeconomic status was shown by a comparison of intraclass correlation coefficients from households in East Baltimore with those from white and black households from the Columbia Medical Plan which have higher levels of occupation and education. Higher correlations were shown for the groups with higher socioeconomic status, regardless of race.

blacks; cholesterol; genetics; human; triglycerides


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 PediatricsHome page
Committee on Nutrition
Cholesterol in Childhood
Pediatrics, January 1, 1998; 101(1): 141 - 147.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.