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American Journal of Epidemiology Vol. 114, No. 2: 234-243
Copyright © 1981 by The Johns Hopkins University School of Hygiene and Public Health

research-article

COST OF CASE-CONTROL STUDIES

ERICA BRITTAIN1, JAMES J. SCHLESSELMAN1 and BRUCE V. STADEL2,2

1Biometry Branch, National Institute of Child Health and Human Development Bethesda, MD.
2Contraceptive Evaluation Branch, National Institute of Child Health and Human Development Bethesda, MD 20205

2Reprint requests to Dr. Stadel

A financial review of five case-control studies concerning the relationship of birth control methods to the occurrence of disease was conducted. The review had two major objectives: first, to identify costs associated with the planning, conduct and analysis of case-control studies; second, to assess whether sample size determination based on optimal allocation would have resulted in a significant reduction in cost. The data collection phase represented about 75% of the total cost of a study, whereas the costs of planning and analysis were roughly 10% and 15% of total cost respectively. The typical cost in mid-1970s dollars was from $100–$200 per subject. Evaluation of an optimal allocation procedure based on the relative cost of cases and controls demonstrated that such a method was likely to reduce total study cost by at most 2 per cent.

costs and cost analysis; retrospective studies; blometry


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