American Journal of Epidemiology Vol. 114, No. 1: 73-80
Copyright © 1981 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
NOSOCOMIAL BLOODSTREAM INFECTIONS IN A NEWBORN INTENSIVE CARE UNIT
A CASE-MATCHED CONTROL STUDY OF MORBIDITY, MORTALITY AND RISK1
Send reprint requests to Dr. Timothy R. Townsend, Department of Pediatrics, Administration 229, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21205
Routine surveillance of 1252 newborns admitted over a four-year period to a newborn intensive care unit (ICU) identified 49 (4%) with nosocomial bloodstream infections. Forty-nine control subjects without such infections were selected, matching for birth weight, gestational age, and at least three diagnoses per patient. Overall, 27% of cases and 6% of controls died (p = 0.01) and significant differences persisted when cases with multiple bloodstream infections were removed from analysis. Although small numbers of case-control pairs remained for analysis, significant differences disappeared when cases with multiple bloodstream infections plus case-control pairs discordant for presence/absence of nosocomial infections at other sites were eliminated from comparison. On the average, all cases and controls were hospitalized for 70 ± 14 days and 50 ± 8 days, respectively, but when cases with multiple bloodstream infections or the multiple bloodstream infections-discordant pair group were removed from analysis, the significant difference in hospitalization disappeared. A strong association between nosocomial infections at sites other than the bloodstream and bloodstream infections was demonstrated and may suggest a means of reducing the incidence of bloodstream infections in a high risk population.
infant; newborn; nosocomial infections; septicemia
1 From the Departments of Pediatrics and Medicine, University of Virginia Medical Center, Charlottesville, VA, and the Center for Disease Control, Atlanta, GA.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. A. Martin, M. A. Pfaller, and R. P. Wenzel Coagulase-Negative Staphylococcal Bacteremia: Mortality and Hospital Stay Ann Intern Med, January 1, 1989; 110(1): 9 - 16. [Abstract] [PDF]
|
|
|
|
 |
|
 D. E. Craven, L. M. Kunches, D. A. Lichtenberg, N. R. Kollisch, M. A. Barry, T. C. Heeren, and W. R. McCabe Nosocomial Infection and Fatality in Medical and Surgical Intensive Care Unit Patients Arch Intern Med, May 1, 1988; 148(5): 1161 - 1168. [Abstract] [PDF]
|
|
|
|
 |
|
 M. E. Evans, W. Schaffner, C. F. Federspiel, R. B. Cotton, K. T. McKee Jr, and C. W. Stratton Sensitivity, Specificity, and Predictive Value of Body Surface Cultures in a Neonatal Intensive Care Unit JAMA, January 8, 1988; 259(2): 248 - 252. [Abstract] [PDF]
|
|
|
|
 |
|
 V. A. FULGINITI and C. G. RAY Body Surface Cultures in the Newborn Infant: An Exercise in Futility, Wastefulness, and Inappropriate Practice Arch Pediatr Adolesc Med, January 1, 1988; 142(1): 19 - 20. [Abstract] [PDF]
|
|
|
|
 |
|
 T. E. Harper and R. D. Christensen Bacterial Sepsis in the Newborn Infant: Developmental Deficiencies in Neutrophils and the Role of Neutrophil Transfusion J Intensive Care Med, September 1, 1987; 2(5): 279 - 291. [Abstract] [PDF]
|
|