Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by REVES, R.
Right arrow Articles by FARER, L. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by REVES, R.
Right arrow Articles by FARER, L. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology Vol. 113, No. 4: 423-435
Copyright © 1981 by The Johns Hopkins University School of Hygiene and Public Health

other

TRANSMISSION OF MULTIPLE DRUG-RESISTANT TUBERCULOSIS: REPORT OF A SCHOOL AND COMMUNITY OUTBREAK

RANDALL REVES1, DURWARD BLAKEY2, DIXIE E. SNIDER, JR.1 and LAURENCE S. FARER1

1Centers for Disease Control, US Public Health Service, Department of Health and Human Services Atlanta, GA 30333
2Bureau of Disease Control, State Board of Health, Jackson MS

Request for reprints should be addressed to the Centers for Disease Control, Attention: Technical Information Services, Bureau of State Services, Atlanta, GA 30333

Reves R. (CDC, Atlanta, GA 30333), D. Blakey, D. E. Snider, Jr., and L. S. Farer. Transmission of multiple drug-resistant tuberculosis: report of a school and community outbreak. Am J Epidemiol 1981; 113: 423-35.

An outbreak of tuberculosis in 1976 was caused by mycobacteria resistant to Isonlazid (INH), streptomycin (SM), and para-amlnosallcylic acid (PAS). High rates of infection associated with exposure to the index case suggested that transmission of resistant organisms had occurred, and the subsequent appearance of bacteriologically proven INH-SM-PAS-resistant tuberculosis in four school contacts of the index case confirmed this fact. Retrospective Investigation revealed that the school outbreak was part of an ongoing community outbreak dating back at least to 1964. Through the use of case histories, drug-susceptlbllity patterns, and phage typing, 15 documented and seven presumed INH-SM-PAS-resistant, epidemioiogically linked cases were found; two of these persons died of tuberculosis. Six additional cases with INH-SM-PAS resistance that could not be epidemiologically linked to the outbreak were also identified. The potential of drug-resistant strains for causing disease in humans should not be underestimated.

drug resistance; ethambutol; Isonlazid; Mycobacterium tuberculosis; paraaminosallcylic acid; rifampin; streptomycin; tuberculosis


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 AJPHHome page
S. Chang, L. S. M. Wheeler, and K. P. Farrell
Public Health Impact of Targeted Tuberculosis Screening in Public Schools
Am J Public Health, December 1, 2002; 92(12): 1942 - 1945.
[Full Text] [PDF]

Home page
 PediatricsHome page
H. S. Schaaf, R. P. Gie, M. Kennedy, N. Beyers, P. B. Hesseling, and P. R. Donald
Evaluation of Young Children in Contact With Adult Multidrug-Resistant Pulmonary Tuberculosis: A 30-Month Follow-up
Pediatrics, May 1, 2002; 109(5): 765 - 771.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
A Telenti
Genetics and pulmonary medicine bullet  5: Genetics of drug resistant tuberculosis
Thorax, September 1, 1998; 53(9): 793 - 797.
[Full Text]

Home page
 NEJMHome page
D. E. Snider and K. G. Castro
The Global Threat of Drug-Resistant Tuberculosis
N. Engl. J. Med., June 4, 1998; 338(23): 1689 - 1690.
[Full Text]

Home page
 PediatricsHome page
H. R. Yusuf, C. R. Braden, A. J. Greenberg, A. C. Weltman, I. M. Onorato, and S. E. Valway
Tuberculosis Transmission Among Five School Bus Drivers and Students in Two New York Counties
Pediatrics, September 1, 1997; 100(3): e9 - e9.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
J. Raffalli, K. A. Sepkowitz, and D. Armstrong
Community-Based Outbreaks of Tuberculosis
Arch Intern Med, May 27, 1996; 156(10): 1053 - 1060.
[Abstract] [PDF]

Home page
 NEJMHome page
M. D. Iseman
Treatment of Multidrug-Resistant Tuberculosis
N. Engl. J. Med., September 9, 1993; 329(11): 784 - 791.
[Full Text]

Home page
 NEJMHome page
P. M. Small, R. W. Shafer, P. C. Hopewell, S. P. Singh, M. J. Murphy, E. Desmond, M. F. Sierra, and G. K. Schoolnik
Exogenous Reinfection with Multidrug-Resistant Mycobacterium tuberculosis in Patients with Advanced HIV Infection
N. Engl. J. Med., April 22, 1993; 328(16): 1137 - 1144.
[Abstract] [Full Text]

Home page
 NEJMHome page
M. Goble, M. D. Iseman, L. A. Madsen, D. Waite, L. Ackerson, and C. R. Horsburgh
Treatment of 171 Patients with Pulmonary Tuberculosis Resistant to Isoniazid and Rifampin
N. Engl. J. Med., February 25, 1993; 328(8): 527 - 532.
[Abstract] [Full Text]

Home page
 ANN INTERN MEDHome page
S. W. Dooley, W. R. Jarvis, W. J. Marione, and D. E. Snider Jr.
Multidrug-resistant Tuberculosis
Ann Intern Med, August 1, 1992; 117(3): 257 - 259.
[Abstract] [PDF]

Home page
 JAMAHome page
Leads from the MMWR
JAMA, June 28, 1985; 253(24): 3521 - 3535.
[PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.