Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by SMITH, J. W.
Right arrow Articles by HOLMQUIST, N. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by SMITH, J. W.
Right arrow Articles by HOLMQUIST, N. D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology Vol. 110, No. 2: 141-147
Copyright © 1979 by The Johns Hopkins University School of Hygiene and Public Health

research-article

ASSOCIATION OF HERPES SIMPLEX VIRUS (HSV) WITH CERVICAL CANCER BY LYMPHOCYTE REACTIVITY WITH HSV-1 AND HSV-2 ANTIGENS

JERRY W. SMITH1,, JOSE E. TORRES2 and NELSON D. HOLMQUIST3

1Department of Microbiology, Louisiana State University Medical Center 1542 Tulane Ave., New Orleans, LA 70112
2Department of Obstetrics and Gynecology, Louisiana State University Medical Center
3Department of Pathology, Louisiana State University Medical Center

Reprint requests to Dr. Smith

Twenty-six women with Invasive cervical cancer were examined for lymphocyte responsiveness to phytohemagglutinin (PHA) herpes simplex virus (HSV). Blood specimens were obtained from each patient before radiation therapy and separated into subpopulations by Ficoli-Hypaque centrifugation. Lymphocytes were cultured in RPMI-1640 containing autologous plasma and exposed to PHA, HSV-1, HSV-2, and control antigens. The results compared with those of women having negative Papanicolaou smears and matched to the cancer patients by age, race, and socioeconomic class revealed significant differences in blastogenic response (3H-thymidine) to HSV-2 antigens. Results from groups with known HSV-1 and HSV-2 infections indicated that differences were associated with the cancer patients having a higher frequency of HSV-2 infection. Results generally agreed with the findings of previous studies in which serologic test procedures were used.

cervix diseases; cervix neoplasms; herpes simplex virus; immunity, cellular; lymphocyte transformation; virus diseases


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.