American Journal of Epidemiology Vol. 109, No. 3: 362-375
Copyright © 1979 by The Johns Hopkins University School of Hygiene and Public Health
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CHOOSING THE PARAMETER FOR A 2 x 2 TABLE OR A 2 x 2 x 2 TABLE ANALYSIS
1 Research performed while the author was on IPA assignment to the Biometry Branch, National Institute of Environmental Health Sciences
Reprint requests to Dr. M. A. Hamilton, Department of Mathematics, Montana State University, Bozeman, MT 59717.
Fourteen 2 x 2 table measures of association are compared and six 2 x 2 x 2 table measures of synergism are compared. The presentation is based on a conceptual population model for the true association between the disease and the risk factor(s). Each measure Is judged as to potential use and identified with the study designs under which it can be estimated. It is shown that prior information about the correct population model is required to adequately measure synergism.
drug synergism; environmental health; epldemiologic methods; research design
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