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American Journal of Epidemiology Vol. 107, No. 6: 522-528
Copyright © 1978 by The Johns Hopkins University School of Hygiene and Public Health

other

CHILDHOOD SIBLING AGGREGATION OF CORONARY ARTERY DISEASE RISK FACTOR VARIABLES IN A BIRACIAL COMMUNITY

CHARLES L. SHEAR1, RALPH R. FRERICHS2, ROGER WEINBERG3 and GERALD S. BERENSON4,

1 Department of Health Measurement Sciences, Tulane University School of Public Health and Tropical Medicine New Orleans, LA
2 Department of Public Health and Preventive Medicine, Louisiana State University Medical Center
3 Department of Biometry, Louisiana State University Medical Center
4 Department of Medicine, Louisiana State University Medical Center New Orleans, LA 70112

4 address for reprint requests.

To analyze aggregation of risk factors for coronary artery disease (CAD), the authors studied 4538 children from the biracial community of Bogalusa, Louisiana. Of these children, ranging In age from two to 18 years, 2535 had at least one sibling, permitting the calculation of F-ratios and Intraclass correlation coefficients. Those calculations revealed statistically significant Fratios for all anthropometric, blood pressure and lipid variables studied. Of the lipoprotein variables studied only {alpha}-lipoprotein showed no statistically significant aggregation (for black children). The analysis failed to reveal any significant differences in Intraclass correlations between black and white children.

arteriosclerosis; blood pressure; genetics; lipids; lipoproteins


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