American Journal of Epidemiology Vol. 107, No. 6: 510-521
Copyright © 1978 by The Johns Hopkins University School of Hygiene and Public Health
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AN EPIDEMIOLOGIC STUDY OF BREAST CANCER1
2 University of Manitoba
3 Epidemiology Unit, National Cancer Institute of Canada
4 University of Saskatchewan
5 University of Toronto
6 University of Sherbrooke
Reprint requests to Dr. Miller, NCIC Epidemiology Unit, University of Toronto, McMurrich Building, Toronto, Ontario M5S 1A8, Canada.
A case-control study has been conducted In four areas of Canada In which 400 cases of breast cancer matched by age and marital status with neighborhood controls were administered medical and dietary questionnaires. The study is suggestive of an Increased risk of breast cancer In post-menopausal women with younger age at menarche and an Increased risk with delay of age at natural menopause. No protective effect of early age at first pregnancy was demonstrated in either pre- or post-menopausal women. An Increased frequency of pregnancies of four months duration or less was found In cases compared to controls and a greater frequency In pre-menopausal cases compared to controls of a history of irregular menstrual periods. In premenopausal women no association has been found between Increased height and weight as risk factors for breast cancer. For post-menopausal women, however, a weak association with Increased height has been found, while a strong association with Increased weight both at the time of menopause and the 12 months preceding diagnosis has been confirmed.
breast neoplasms; cancer; epidemiology
1 This study was supported by the National Cancer Institute of Canada and in part under National Health Research and Development Project No. 613-1047-30 of the Department of NATIONAL Health and Welfare of Canada.
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