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American Journal of Epidemiology Vol. 107, No. 5: 439-443
Copyright © 1978 by The Johns Hopkins University School of Hygiene and Public Health

other

A COMPARISON OF A WI-38 VACCINE AND DUCK EMBRYO VACCINE FOR PREEXPOSURE RABIES PROPHYLAXIS

BARRY HAFKIN1, MICHAEL A. W. HATTWICK1, JEAN S. SMITH2, MERRY ELLEN ALLS2, PAMELA A. YAGER2, LAWRENCE COREY1, CHARLES H. HOKE1 and GEORGE M. BAER2,

1 Viral Diseases Division, Bureau of Epidemiology, Center for Disease Control, Public Health Service, Department of Health, Education, and Welfare Atlanta, GA 30333
2 Viral Zoonoses Branch, Virology Division, Bureau of Laboratories, Center for Disease Control (Lawrenceville Facility) P.O. Box 363, Lawrenceville, GA 30246

2 Reprint requests to Dr. Baer at this address.

Two types of rabies vaccine, WI-38 vaccine (WRV) and Duck Embryo Vaccine (DEV) were compared In rabies preexposure prophylaxis. One group of veterinary students received four doses of DEV, a second group received four doses of WRV, and a third group received two doses of WRV. Adverse reactions were found to be similar for all three groups. The antibody responses, however, differed markedly: the mean neutralizing titer after four doses of DEV was 1:75, after four doses of WRV was 1:1517, but was only 1:164 after two doses of WRV. All students who received three or four doses of WRV developed high titers of rabies antibody, making this vaccine very desirable for preexposure prophylaxis.

antibodies; lmmune globulin; rabies; vaccination


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