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American Journal of Epidemiology Advance Access originally published online on March 15, 2008
American Journal of Epidemiology 2008 167(8):1016; doi:10.1093/aje/kwn039
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American Journal of Epidemiology © The Author 2008. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

LETTERS TO THE EDITOR

FOUR AUTHORS REPLY

Karen L. Margolis1, Juhua Luo2, Weimin Ye2, Hans-Olov Adami2,3 for the Women's Health Initiative Investigators

1 HealthPartners Research Foundation, Minneapolis, MN 55440-1524
2 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE 171 77, Stockholm, Sweden
3 Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115

(e-mail: juhua.luo{at}ki.se)

We thank Sharifi and Farrar for their interest (1) in our article (2) and for pointing out an additional mechanism by which central adiposity might predispose toward the development of renal cell carcinoma (RCC). They speculate that hypoxia-inducible factors may play a role in sporadic RCC as well as in hereditary clear cell RCC cancers associated with von Hippel-Lindau syndrome. This might also account for the association between smoking and RCC. Although their suggestion that obesity and central adiposity might also be linked to RCC via hypoxia induced by sleep apnea is intriguing, we do not have data from the Women's Health Initiative to support this hypothesis, as data on sleep apnea were not collected.


   ACKNOWLEDGMENTS
 
Conflict of interest: none declared.


   References
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 References
 

  1. Sharifi N, Farrar WL. Re: "Body size, weight cycling, and risk of renal cell carcinoma among postmenopausal women: the Women's Health Initiative (United States)." (Letter). Am J Epidemiol (2008) 167:1016.[Free Full Text]
  2. Luo J, Margolis KL, Adami HO, et al. Body size, weight cycling, and risk of renal cell carcinoma among postmenopausal women: the Women's Health Initiative (United States). Am J Epidemiol (2007) 166:752–9.[Abstract/Free Full Text]

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This Article
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Right arrow All Versions of this Article:
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