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American Journal of Epidemiology Advance Access originally published online on September 4, 2006
American Journal of Epidemiology 2006 164(8):728-730; doi:10.1093/aje/kwj272
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American Journal of Epidemiology Copyright © 2006 by the Johns Hopkins Bloomberg School of Public Health All rights reserved; printed in U.S.A.

Invited Commentary

Invited Commentary: Evaluation of Measures of Urinary Albumin Excretion in Epidemiologic Studies

Alan R. Dyer

From the Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL

Correspondence to Dr. Alan R. Dyer, Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N. Lake Shore Drive, Suite 1102, Chicago, IL 60611-4402 (e-mail: adyer@northwestern.edu).

Received for publication February 1, 2006. Accepted for publication February 13, 2006.

Abbreviations: INTERMAP, International Study of Macronutrients and Blood Pressure; PREVEND-IT, Prevention of Renal and Vascular Endstage Disease Intervention Trial

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In the current issue of the Journal, Gansevoort et al. (1Go) raise concerns about our paper (2Go) that compared the strengths and weaknesses of the urinary albumin concentration and the albumin:creatinine ratio as alternatives to the "gold standard" 24-hour urinary albumin excretion in the International Study of Macronutrients and Blood Pressure (INTERMAP). In that report, which used albumin excretion measures from two 24-hour urine collections, we found that 1) the median within-person coefficient of variation ranged from 25.3 to 81.3 percent for the three measures, with the albumin concentration generally having slightly smaller within-person coefficients of variation; 2) the albumin:creatinine ratio had larger rank-order correlations with 24-hour excretion than did the urinary albumin concentration (0.949 for men and 0.942 for women vs. 0.881 and 0.816 for the albumin concentration); and 3) the average correlations with blood pressure were similar for the three measures, but the correlation with . . . [Full Text of this Article]


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Related articles in Am. J. Epidemiol.:

Evaluation of Measures of Urinary Albumin Excretion
Ronald T. Gansevoort, Jacoline Brinkman, Stephan J. L. Bakker, Paul E. De Jong, and Dick de Zeeuw
Am. J. Epidemiol. 2006 164: 725-727. [Abstract] [FREE Full Text]  



This article has been cited by other articles:


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 Am J EpidemiolHome page
R. T. Gansevoort, J. Brinkman, S. J. L. Bakker, P. E. De Jong, and D. de Zeeuw
Gansevoort et al. Respond to "Using Measures of Albumin Excretion"
Am. J. Epidemiol., October 15, 2006; 164(8): 731 - 732.
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