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American Journal of Epidemiology Advance Access originally published online on March 22, 2006
American Journal of Epidemiology 2006 163(9):873-874; doi:10.1093/aje/kwj130
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American Journal of Epidemiology Copyright © 2006 by the Johns Hopkins Bloomberg School of Public Health All rights reserved; printed in U.S.A.

Letter to the Editor

RE: "FAMILIAL RISK OF MULTIPLE SCLEROSIS: A NATIONWIDE COHORT STUDY"

Kari Hemminki1,2, Xinjun Li3, Sven-Erik Johansson3, Kristina Sundquist3 and Jan Sundquist3

1 Division of Molecular Genetic Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany
2 Department of Biosciences at Novum, Karolinska Institute, S-141 57 Huddinge, Sweden
3 Center for Family Medicine, Karolinska Institute, S-141 57 Stockholm, Sweden

(e-mail: k.hemminki@dkfz.de)

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In a recent register-based Danish cohort study on multiple sclerosis, Nielsen et al. (1Go) reported a 7.1-fold increased risk of multiple sclerosis in first-degree relatives of multiple sclerosis patients and an 8.6-fold risk in nontwin siblings. Brothers had a high relative risk of 12.6, as compared with sisters' risk of 6.3. The study was based on the Danish Multiple Sclerosis Register for diagnostic data and on the Danish Civil Registration System for family data, available for persons born in the early 1950s. No age-specific data were given, but, . . . [Full Text of this Article]


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