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American Journal of Epidemiology Advance Access originally published online on April 26, 2006
American Journal of Epidemiology 2006 163(11):1067-1068; doi:10.1093/aje/kwj156
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American Journal of Epidemiology Copyright © 2006 by the Johns Hopkins Bloomberg School of Public Health All rights reserved; printed in U.S.A.

Letter to the Editor

RE: "COMBINED POSTMENOPAUSAL HORMONE THERAPY AND CARDIOVASCULAR DISEASE: TOWARD RESOLVING THE DISCREPANCY BETWEEN OBSERVATIONAL STUDIES AND THE WOMEN'S HEALTH INITIATIVE CLINICAL TRIAL"

Walter C. Willett1,2,3, JoAnn E. Manson2,3,4, Francine Grodstein2,3, Meir J. Stampfer1,2,3 and Graham A. Colditz2,3

1 Department of Nutrition, Harvard School of Public Health, Boston, MA 02115
2 Channing Laboratory, Boston, MA 02115
3 Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115
4 Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215

(e-mail: walter.willett@channing.harvard.edu)

The first 10% of the full text of this article appears below.

We appreciate the effort by Prentice et al. (1Go) to elucidate the basis for differences in the relation of postmenopausal hormone therapy to risk of coronary heart disease in observational studies and in the Women's Health Initiative (WHI) trial. Three findings from this and earlier WHI reports (2Go–4Go) are key.

First, the duration of time since starting hormone therapy differed greatly between the types of studies, in part because the observational studies enrolled a cross-section of postmenopausal women that included many who had already been using . . . [Full Text of this Article]


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