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American Journal of Epidemiology Advance Access originally published online on June 22, 2005
American Journal of Epidemiology 2005 162(2):195-196; doi:10.1093/aje/kwi176
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American Journal of Epidemiology Copyright © 2005 by the Johns Hopkins Bloomberg School of Public Health All rights reserved

LETTERS TO THE EDITOR

RE: "ETHICS AND SAMPLE SIZE"

Scott D. Halpern1,2,3,4, Jason H. T. Karlawish1,2,4 and Jesse A. Berlin2,5

1 Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6021
2 Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6021
3 Center for Education and Research on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6021
4 Center for Bioethics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6021
5 Johnson & Johnson Pharmaceutical Research & Development, LLC, Titusville, NJ 08560

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We were gratified to see in the January 15, 2005, issue of the Journal further discussion of the ethics of conducting clinical trials that are underpowered to reliably detect clinically important treatment differences (1Go, 2Go). Unfortunately, Bacchetti et al.'s central argument, that "smaller sample sizes have a more favorable ethical balance [than larger ones]" (1Go, p. 106), is based on conceptions . . . [Full Text of this Article]


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P. Bacchetti, L. E. Wolf, M. R. Segal, and C. E. McCulloch
THE AUTHORS REPLY
Am. J. Epidemiol., July 15, 2005; 162(2): 196 - 196.
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