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Am J Epidemiol 2004; 159:1107-1108.
Copyright © 2004 by the Johns Hopkins Bloomberg School of Public Health

LETTERS TO THE EDITOR

RE: "FLEXIBLE MATCHING STRATEGIES TO INCREASE POWER AND EFFICIENCY TO DETECT AND ESTIMATE GENE-ENVIRONMENT INTERACTIONS IN CASE-CONTROL STUDIES"

Walter Schill1 and Pascal Wild2

1 Bremer Institut für Präventionsforschung und Sozialmedizin (BIPS), Universität Bremen, Linzer Str. 8–10, D-28359 Bremen, Germany
2 Department of Epidemiology, Institut National de Recherche et de Sécurité pour la Prévention des Accidents du Travail et des Maladies Professionelles (INRS), Avenue de Bourgogne, 54501 Vandoeuvre Cedex, France

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To increase the power and efficiency in case-control studies exploring gene-environment interaction, Stürmer and Brenner advocated "flexible matching strategies" (1, pp. 600–601) with varying proportions of a matching factor among selected controls. In essence, they advocate biased sampling of control persons with respect to environmental exposure and developed a measure DM (degree of matching) that describes . . . [Full Text of this Article]


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T. Sturmer and H. Brenner
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Am. J. Epidemiol., June 1, 2004; 159(11): 1108 - 1108.
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