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Am J Epidemiol 2003; 158:512-513.
Copyright © 2003 by Johns Hopkins Bloomberg School of Public Health

ORIGINAL CONTRIBUTIONS

Doria-Rose and Edwards Respond to "Parity and Down’s Syndrome"

V. Paul Doria-Rose1,2  and Karen L. Edwards1

1 Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA.
2 Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.

Received for publication May 14, 2003; accepted for publication May 23, 2003.

The first 10% of the full text of this article appears below.

We agree with Dr. Chan (1) that our findings (2) should be interpreted cautiously, based on issues of underascertainment in our data. We accounted for differential termination of Down’s syndrome pregnancies between low-parity and high-parity women by attempting to exclude women who had received prenatal diagnosis. Unfortunately, our data sources could not identify all such women. Thus, our adjustment for the differential termination . . . [Full Text of this Article]


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Related articles in Am. J. Epidemiol.:

Parity and the Risk of Down’s Syndrome
V. Paul Doria-Rose, Han S. Kim, Elizabeth T. J. Augustine, and Karen L. Edwards
Am. J. Epidemiol. 2003 158: 503-508. [Abstract] [FREE Full Text]  

Invited Commentary: Parity and the Risk of Down’s Syndrome—Caution in Interpretation
Annabelle Chan
Am. J. Epidemiol. 2003 158: 509-511. [Extract] [FREE Full Text]