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Am J Epidemiol 2003; 158:301-304.
Copyright © 2003 by Johns Hopkins Bloomberg School of Public Health


ORIGINAL CONTRIBUTIONS

Invited Commentary: Gaining Traction on the Epidemiologic Landscape of Schizophrenia

John J. McGrath 

From the Queensland Centre for Schizophrenia Research, University of Queensland, Wacol, Australia.

Received for publication March 18, 2003; accepted for publication April 11, 2003.

The first 150 words of the full text of this article appear below.

Background
In his scholarly review of the field, Jablensky (1) outlined how the wealth of epidemiologic data about schizophrenia has enriched the "epidemiological horizon" of schizophrenia. This metaphor reminds us of how essential it is to chart the epidemiologic gradients across time and space in order to guide research. In this commentary, I argue that the task for the researcher is not only to continue to refine this map but also to gain "traction" on this landscape to generate, and test, candidate risk factors for schizophrenia.

Schizophrenia is a group of imperfectly understood brain disorders characterized by alterations in higher functions related to perception, cognition, communication, planning, and motivation. The syndrome is defined reliably (if not validly) by applying diagnostic criteria related to the presence of hallucinations, delusions, thought disorder, and negative symptoms such as blunted affect and reduced speech (2). Symptoms of the disorder (which has . . . [Full Text of this Article]

Early life exposures and schizophrenia risk

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