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Am J Epidemiol 2003; 158:1033-1035.
Copyright © 2003 by the Johns Hopkins Bloomberg School of Public Health

COMMENTARY

Invited Commentary: Making the Most of Genotype Asymmetries

Clarice Weinberg 

From the National Institute of Environmental Health Sciences, Research Triangle Park, NC.

Received for publication August 14, 2003; accepted for publication August 28, 2003.

The first 150 words of the full text of this article appear below.


   INTRODUCTION
 
Designs that use family members as genetic controls offer appealing advantages. Family members are often easy to contact and more than willing to participate. They also tend to be well matched to the case on other factors, such as ethnicity. At the same time, unrelated population-based controls may become harder to reach and to recruit for genetic studies, because of the increasing popularity of screening devices such as answering machines and increased concerns about potential abuses of genetic data. Consequently, a population-based case-control design can let the investigator down by failing to provide a high-enough control recruitment rate for the findings to be trustworthy.

One family-based approach genotypes cases and their parents, relying on the fact that any allele related to increased risk (either directly or through linkage disequilibrium with a nearby disease-susceptibility allele) will appear to have been transmitted too often (i.e., more than half the time) by heterozygous . . . [Full Text of this Article]


   ACKNOWLEDGMENTS
 

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