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Am J Epidemiol 2002; 156:883-884.
Copyright © 2002 by Johns Hopkins Bloomberg School of Public Health

LETTERS TO THE EDITOR

THE AUTHORS REPLY

Wilfried Karmaus1, Hasan Arshad2 and Jörg Mattes3

1 Department of Epidemiology, College of Human Medicine, Michigan State University, East Lansing, MI 48823.
2 The David Hide Asthma and Allergy Research Centre, St. Mary’s Hospital, Newport, Isle of Wight, PO30 STG, United Kingdom.
3 University Children’s Hospital, Mathildenstrasse 1, D-79106 Freiburg, Germany.

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We appreciate the observations of Drs. Maziak (1), Bernsen and van der Wouden (2), and van Noord (3). The innovative character of recent research on asthma etiology is challenging. Mechanistically based hypothesis-driven research, highly respected in the United States, has not stimulated the detection of the sibling effect, since the mechanisms are still unknown and detection is based purely on epidemiologic findings. The world of intuition is less restricted, and there is little chance of being counterintuitive; however, there is a greater likelihood of being countermechanistic when challenging the paradigm of . . . [Full Text of this Article]


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