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American Journal of Epidemiology Vol. 155, No. 10 : 977-979
Copyright © 2002 by The Johns Hopkins University School of Hygiene and Public Health

LETTERS TO THE EDITOR

RE: "PRESENTING STATISTICAL UNCERTAINTY IN TRENDS AND DOSE-RESPONSE RELATIONS"

John L. Hopper and Gillian S. Dite

The University of Melbourne Centre for Genetic Epidemiology Carlton, Victoria 3053, Australia

We thank Greenland et al. (1Go) for drawing attention to the "floating absolute risk" (FAR) method for presenting statistical uncertainty in trends and dose-response relations, originally introduced by Easton et al. (2Go). This is an important tool for assessing the pattern of risk when there is no obvious "unexposed" referent category, such as for a continuously distributed risk factor. It can also help determine the most likely mode of inheritance from genotype data generated by common variants (polymorphisms) (3Go).

We have developed a simple method, using standard statistical software and simple calculations, for deriving approximate confidence intervals for the floating log odds ratios for different categories from an unmatched case-control study, while concurrently adjusting for other measured covariates (4Go). Let the risk factor of major interest be categorized into . . . [Full Text of this Article]

References

Sander Greenland, Karin B. Michels, Charles Poole, James M. Robins and Walter C. Willett

Departments of Epidemiology and Statistics University of California Los Angeles, CA 90095-1772
Obstetrics and Gynecology Epidemiology Center Brigham and Women's Hospital Harvard Medical School Boston, MA 02115
Department of Epidemiology UNC School of Public Health Chapel Hill, NC 27599-7400
Departments of Epidemiology and Biostatistics Harvard School of Public Health Boston, MA 02115
Channing Laboratory Harvard School of Medicine Boston, MA 02115


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J. L. Hopper, G. S. Dite, S. Greenland, K. B. Michels, C. Poole, J. M. Robins, and W. C. Willett
RE: "PRESENTING STATISTICAL UNCERTAINTY IN TRENDS AND DOSE-RESPONSE RELATIONS"
Am. J. Epidemiol., May 15, 2002; 155(10): 977 - 979.
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