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American Journal of Epidemiology Vol. 154, No. 3 : 288-290
Copyright © 2001 by The Johns Hopkins University School of Hygiene and Public Health

LETTERS TO THE EDITOR

RE: ALUMINUM IN DRINKING WATER AND COGNITIVE DECLINE IN ELDERLY SUBJECTS: THE PAQUID COHORT

Virginie Rondeau, Hélène Jacqmin-Gadda, Daniel Commenges and Jean-François Dartigues

INSERM Unité 330, case 11 Université Victor Segalen-Bordeaux II 146 rue Léo Saignat 33076 Bordeaux Cedex, France


   INTRODUCTION
 
Although the neurotoxicity of aluminum has been proved (1Go), the link between aluminum and the risk of Alzheimer's disease is still debated (2Go). A related hypothesis has been put forward by Birchall and Chappell (3Go): silicon in water could be a protective factor against aluminum toxicity.

We recently reported a significant association between the concentration of aluminum in drinking water and the incidence of dementia and Alzheimer's disease (4Go). These results were based on a cohort of 3,777 elderly subjects followed up for 8 years.

In the present study, we have evaluated in the Paquid cohort the association between aluminum in drinking water and the 8-year evolution of . . . [Full Text of this Article]


   REFERENCES
 

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V. Rondeau, H. Jacqmin-Gadda, D. Commenges, C. Helmer, and J.-F. Dartigues
Aluminum and Silica in Drinking Water and the Risk of Alzheimer's Disease or Cognitive Decline: Findings From 15-Year Follow-up of the PAQUID Cohort
Am. J. Epidemiol., February 15, 2009; 169(4): 489 - 496.
[Abstract] [Full Text] [PDF]