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American Journal of Epidemiology Vol. 154, No. 3 : 287-288
Copyright © 2001 by The Johns Hopkins University School of Hygiene and Public Health

LETTERS TO THE EDITOR

RE: "BIASED TESTS OF ASSOCIATION: COMPARISONS OF ALLELE FREQUENCIES WHEN DEPARTING FROM HARDY-WEINBERG PROPORTIONS"

Michael Knapp

Institute for Medical Biometry Informatics and Epidemiology University of Bonn D-53105 Bonn, Germany


   INTRODUCTION
 
The most popular method of analysis in genetic case-control association studies is to compare allele frequencies between cases and controls by using Pearson's chi-square statistic. Sasieni (1Go) has pointed out that this analysis is appropriate only when Hardy-Weinberg equilibrium holds. Therefore, he recommended using Armitage's trend test (2Go) instead.

In a recent article in the Journal, Schaid and Jacobsen (3Go) quantified the effect on the type I error rate of Pearson's chi-square test induced by deviations from . . . [Full Text of this Article]


   REFERENCES
 
Daniel J. Schaid and Steven J. Jacobsen

Department of Health Sciences Research Mayo Clinic Rochester, MN 55905


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 Am J EpidemiolHome page
M. Knapp, D. J. Schaid, and S. J. Jacobsen
RE: "BIASED TESTS OF ASSOCIATION: COMPARISONS OF ALLELE FREQUENCIES WHEN DEPARTING FROM HARDY-WEINBERG PROPORTIONS"
Am. J. Epidemiol., August 1, 2001; 154(3): 287 - 288.
[Full Text] [PDF]