American Journal of Epidemiology Vol. 152, No. 7 : 689-690
Copyright © 2000 by The Johns Hopkins University School of Hygiene and Public Health
LETTERS TO THE EDITOR |
RE: "ASYMPTOTIC BIAS AND EFFICIENCY IN CASE-CONTROL STUDIES OF CANDIDATE GENES AND GENE-ENVIRONMENT INTERACTIONS: BASIC FAMILY DESIGNS"
Biostatistics Branch National Institute of Environmental Health Sciences Research Triangle Park, NC 27709
A paper in the Journal by Witte et al. (1
) considered family-based designs for studying genetic relative risks and gene-by-environment interactions. The authors assessed three options for controls: unaffected siblings of cases, unaffected cousins of cases, and "pseudosiblings" of cases. Pseudosiblings are the three other genetically possible siblings the case proband could equally likely have had, based on the genotypes of the proband's two parents. Witte et al. provided statistical relative efficiencies for these designs compared with a population-based case-control design (1). Their results should be valuable to epidemiologists planning a study involving genetic factors and possible gene-by-environment interaction.
Some readers may be unfamiliar with the pseudosib design. With
REFERENCES
Department of Epidemiology and Biostatistics Case Western Reserve University Cleveland, OH 44109-1998
Department of Preventive Medicine University of Southern California Los Angeles, CA 90033
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