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American Journal of Epidemiology Vol. 152, No. 3 : 290-293
Copyright © 2000 by The Johns Hopkins University School of Hygiene and Public Health

LETTERS TO THE EDITOR

RE: "DOES ARSENIC EXPOSURE INCREASE THE RISK FOR CIRCULATORY DISEASE?"

Jay H. Lubin and Joseph F. Fraumeni, Jr.

Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Bethesda, MD 20892


   INTRODUCTION
 
High levels of ingested inorganic arsenic in drinking water have been linked to arsenical dermatosis and to elevated risks of cancers of the skin, bladder, kidney, liver, and lung (1Go), as well as to diabetes mellitus (2Go, 3Go) and peripheral vascular and cardiovascular disease, but not cerebrovascular disease (4GoGo–6Go). Recently, Hertz-Picciotto et al. (7Go) observed that while high levels of arsenic in drinking water increase risk for a variety of diseases, most occupational studies of arsenic, in which inhalation is the primary route of exposure, have shown excess mortality only for respiratory cancer. This observation agrees with our summarization of 11 occupational studies of arsenic-exposed workers that showed consistent excesses only for respiratory cancer (8Go). Despite results to date, the hypothesis of a deleterious effect of inhaled arsenic for diseases other than respiratory cancer remains credible. . . . [Full Text of this Article]


   REFERENCES
 
Irva Hertz-Picciotto, Suh-Woah Hu and H. M. Arrighi

Department of Epidemiology School of Public Health University of North Carolina Chapel Hill, NC 27599–7400
School of Dentistry Chung Shan Medical and Dental College Taichung, Taiwan 402
Amgen Thousand Oaks, CA 91320–1789


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[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
J. H. Lubin, J. F. Fraumeni Jr., I. Hertz-Picciotto, S.-W. Hu, and H. M. Arrighi
RE: "DOES ARSENIC EXPOSURE INCREASE THE RISK FOR CIRCULATORY DISEASE?"
Am. J. Epidemiol., August 1, 2000; 152(3): 290 - 293.
[Full Text] [PDF]