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American Journal of Epidemiology Advance Access originally published online on June 26, 2009
American Journal of Epidemiology 2009 170(4):501-506; doi:10.1093/aje/kwp153
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American Journal of Epidemiology © 2009 The Authors
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

ORIGINAL CONTRIBUTIONS

Mortality Rates Among Trichlorophenol Workers With Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin

James J. Collins, Kenneth Bodner, Lesa L. Aylward, Michael Wilken and Catherine M. Bodnar

Correspondence to Dr. James J. Collins, Epidemiology Department, The Dow Chemical Company, 1803 Building, Midland, MI 48674 (e-mail: jjcollins{at}dow.com).

Received for publication February 9, 2009. Accepted for publication May 11, 2009.

The authors examined 1,615 workers exposed to dioxins in trichlorophenol production in Midland, Michigan, to determine if there were increased mortality rates from exposure. Historical dioxin levels were estimated by a serum survey of workers. Vital status was followed from 1942 to 2003, and cause-specific death rates and trends with exposure were evaluated. All cancers combined (standardized mortality ratio (SMR) = 1.0, 95% confidence interval (CI): 0.8, 1.1), lung cancers (SMR = 0.7, 95% CI: 0.5, 0.9), and nonmalignant respiratory disease (SMR = 0.8, 95% CI: 0.6, 1.0) were at or below expected levels. Observed deaths for leukemia (SMR = 1.9, 95% CI: 1.0, 3.2), non-Hodgkin lymphoma (SMR = 1.3, 95% CI: 0.6, 2.5), diabetes (SMR = 1.1, 95% CI: 0.6, 1.8), and ischemic heart disease (SMR = 1.1, 95% CI: 0.9, 1.2) were slightly greater than expected. No trend was observed with exposure for these causes of death. However, for 4 deaths of soft tissue sarcoma (SMR = 4.1, 95% CI: 1.1, 10.5), the mortality rates increased with exposure. The small number of deaths and the uncertainty in both diagnosis and nosology coding make interpretation of this finding tenuous. With the exception of soft tissue sarcoma, the authors found little evidence of increased disease risk from exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

dioxins; neoplasms; phenols; sarcoma; tetrachlorodibenzodioxin

Abbreviations: CI, confidence interval; IARC, International Agency for Research on Cancer; SMR, standardized mortality ratio; 2,4,5-T, 2,4,5-trichlorophenoxyacetic acid; TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin; TCP, 2,4,5-trichlorophenol


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 Am J EpidemiolHome page
P. J. Villeneuve and K. Steenland
RE: "MORTALITY RATES AMONG TRICHLOROPHENOL WORKERS WITH EXPOSURE TO 2,3,7,8-TETRACHLORODIBENZO-p-DIOXIN"
Am. J. Epidemiol., January 1, 2010; 171(1): 129 - 130.
[Full Text] [PDF]

Home page
 Am J EpidemiolHome page
J. J. Collins, K. Bodner, and L. L. Aylward
THREE AUTHORS REPLY
Am. J. Epidemiol., January 1, 2010; 171(1): 130 - 131.
[Full Text] [PDF]


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