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American Journal of Epidemiology Advance Access originally published online on November 5, 2008
American Journal of Epidemiology 2009 169(2):167-175; doi:10.1093/aje/kwn297
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American Journal of Epidemiology © The Author 2008. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

ORIGINAL CONTRIBUTIONS

Residence Near Power Lines and Mortality From Neurodegenerative Diseases: Longitudinal Study of the Swiss Population

Anke Huss, Adrian Spoerri, Matthias Egger, Martin Röösli and for the Swiss National Cohort Study

Correspondence to Dr. Anke Huss, Institute of Social and Preventive Medicine, University of Bern, Finkenhubelweg 11, CH-3012 Bern, Switzerland (e-mail: ahuss{at}ispm.unibe.ch).

Received for publication May 5, 2008. Accepted for publication August 25, 2008.

The relation between residential magnetic field exposure from power lines and mortality from neurodegenerative conditions was analyzed among 4.7 million persons of the Swiss National Cohort (linking mortality and census data), covering the period 2000–2005. Cox proportional hazard models were used to analyze the relation of living in the proximity of 220–380 kV power lines and the risk of death from neurodegenerative diseases, with adjustment for a range of potential confounders. Overall, the adjusted hazard ratio for Alzheimer's disease in persons living within 50 m of a 220–380 kV power line was 1.24 (95% confidence interval (CI): 0.80, 1.92) compared with persons who lived at a distance of 600 m or more. There was a dose-response relation with respect to years of residence in the immediate vicinity of power lines and Alzheimer's disease: Persons living at least 5 years within 50 m had an adjusted hazard ratio of 1.51 (95% CI: 0.91, 2.51), increasing to 1.78 (95% CI: 1.07, 2.96) with at least 10 years and to 2.00 (95% CI: 1.21, 3.33) with at least 15 years. The pattern was similar for senile dementia. There was little evidence for an increased risk of amyotrophic lateral sclerosis, Parkinson's disease, or multiple sclerosis.

dementia; neurodegenerative diseases; radiation, nonionizing


Abbreviations: ALS, amyotrophic lateral sclerosis; CI, confidence interval; ELF-MF, extremely low frequency magnetic field(s); ICD-10, International Classification of Diseases, Injuries, and Causes of Death, Tenth Revision


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