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American Journal of Epidemiology Advance Access published online on June 27, 2008
American Journal of Epidemiology, doi:10.1093/aje/kwn134
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American Journal of Epidemiology © The Author 2008. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

Original Contribution

Consumption of trans-Fatty Acid and Its Association with Colorectal Adenomas

Lisa C. Vinikoor1,2, Jane C. Schroeder1, Robert C. Millikan1, Jessie A. Satia1,2,3, Christopher F. Martin2, Joseph Ibrahim4, Joseph A. Galanko2 and Robert S. Sandler2

1 Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC
2 Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina, Chapel Hill, NC
3 Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, NC
4 Department of Biostatistics, School of Public Health, University of North Carolina, Chapel Hill, NC

Correspondence to Lisa C. Vinikoor, Campus Box 7555, Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina, Chapel Hill, NC 27599-7555 (e-mail: vinikoor{at}email.unc.edu).

Received for publication January 15, 2008. Accepted for publication April 22, 2008.

trans-Fatty acid consumption is known to have detrimental effects on cardiovascular health, but little is known about its role in digestive tract neoplasia. To investigate the association between colorectal adenomas and trans-fatty acid consumption, the authors utilized data from a cross-sectional study of 622 individuals who underwent complete colonoscopy between 2001 and 2002 at the University of North Carolina Hospitals. Participants were interviewed about demographic, lifestyle, and dietary factors thought to be related to colorectal cancer. trans-Fatty acid consumption, energy adjusted by the residual method, was categorized into quartiles based on its distribution in controls. Compared with participants in the lowest quartile of consumption, those in the highest quartile had an increased prevalence of colorectal adenomas, with an adjusted prevalence odds ratio of 1.86 (95% confidence interval: 1.04, 3.33). The authors further investigated the relation between trans-fatty acid consumption and colorectal neoplasia by examining the adenoma characteristics, with the adjusted prevalence odds ratios showing little or no difference by adenoma location, size, or number. These results suggest that consumption of high amounts of trans-fatty acid may increase the risk of colorectal neoplasia, and they provide additional support to recommendations to limit trans-fatty acid consumption.

colonic polyps; colorectal neoplasms; dietary fats; trans fatty acids

Abbreviations: CI, confidence interval; NSAID, nonsteroidal antiinflammatory drug; UNC, University of North Carolina


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