Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by VILLAREJOS, V. M.
Right arrow Articles by HILLEMAN, M. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by VILLAREJOS, V. M.
Right arrow Articles by HILLEMAN, M. R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology Vol. 93, No. 5: 384-391
Copyright © 1971 by The Johns Hopkins University School of Hygiene and Public Health

other

FIELD EVALUATION OF COMBINED MORE ATTENUATED LIVE MEASLES (MORATEN)-SMALLPOX VACCINE IN HONDURAS AND COSTA RICA1

VICTOR M. VILLAREJOS, ANTONIO RODRIGUEZ-ARAGONÉS, NAPOLEÓN GÚNERA, JORGE A. ARGUEDAS, EUGENE B. BUYNAK and MAURICE R. HILLEMAN2

2Reprint requests to Dr. Hilleman, Division of Virus and Cell Biology Research, Merck Institute for Therapeutic Research, West Point, Pennsylvania 19486.

Villarejos, V. M., A. Rodríguez-Aragonés, N. Gúnera, J. A. Arguedas G., E. B. Buynak and M. R. Hilleman (Merck Institute for Therapeutic Research, West Point, Pa. 19486). Field evaluation of combined more attenuated live measles (Mora-ten)-smallpox vaccine in Honduras and Costa Rica. Amer J Epidem 93: 384–391, 1971.—Four lots of premixed and lyophilized preparations of Moraten line Enders' live measles virus vaccine combined with calf lymph smallpox vaccine were evaluated in clinical studies carried out among children in Costa Rica and Honduras. Careful study was made of 354 children who were initially seronega-tive for both viruses and 560 children who bore a previous vaccination scar. Additionally, 1096 children who gave a negative history for measles and smallpox were given vaccine but observed only for evolution of the dermal lesion and for clinical reaction. The combined vaccine was highly effective in eliciting antibodies against both viruses in initially seronegative children. All children developed local lesions to the vaccinia component and nearly all gave immune or vaccinoid reactions on subsequent challenge with smallpox vaccine by multiple puncture. Further, the bivalent vaccine was adequate to elicit dermal reactions In nearly all persons with a previous smallpox vaccination scar. The febrile responses to combined vaccine were no greater than expected for either vaccine given alone. It was concluded that the Moraten measles and smallpox vaccine in combined form can be safely and effectively administered via jet gun with considerable savings in time and with minimal discomfort.

measles vaccine; smallpox vaccine; vaccines; evaluation

1From the Louisiana State University International Center for Medical Research and Training, San Jose, Costa Rica; and the Division of Virus and Cell Biology Research, Merck Institute for Therapeutic Research, West Point, Pennsylvania.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.