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American Journal of Epidemiology Vol. 93, No. 4: 298-307
Copyright © 1971 by The Johns Hopkins University School of Hygiene and Public Health

other

HERPESVIRUS INFECTION OF GUINEA PIGS1,2

I. ISOLATION, CHARACTERIZATION AND PATHOGENICITY

G. D. HSIUNG, L. S. KAPLOW and J. BOOSS3

3Recipient of Special Fellowship Support from National Institute of Neurological Diseases and Blindness, No. 1 F11 NB 2083-01, NIH

Hsiung, G. D. (VA Hospital, West Haven, Conn. 06516), L S. Kaplow and J. Booss. Herpesvirus infection of guinea pigs. I. Isolation, characterization and pathogenicity. Amer J Epidem 93: 298–307, 1971.—In a survey study of over 200 guinea pigs of five different strains obtained from various sources, over 90% of strain 2 and 35% of muta strain guinea pigs showed a herpes-like virus infection. Isolation of the virus from infected animals required cultivation or co-cultivation of tissue cells. The virus was found to have a relatively narrow host range. Extensive cytopathic effect and high titer of virus yield were obtained in guinea pig and rabbit cell cultures. Primary cell cultures derived from other animal species including man, monkey, hamster and mouse as well as embryonated chicken eggs showed no cytopathic effect with this virus and virus titers, if any, were low. Virus was found widely distributed in the various tissues and organs as well as in white blood cells of infected animals in the presence of circulating neutralizing antibody. Non-strain 2 guinea pigs, including Hartley and FS, can be easily infected experimentally with the guinea pig herpes-like virus (GPHLV) isolated from strain 2 animals. Virus persisted in the white blood cells and tissues of inoculated guinea pigs for as long as 10 months without any evidence of clinical disease.

guinea pigs; herpesvirus; herpes-like virus; viruses

1This investigation was supported by USPHS Research Grant AI-08648 and Research Contract NIH69-2045 from the Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, and Veterans Administration Research Funds.

2From the Section of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut, and Veterans Administration Hospital, West Haven, Connecticut 06616. (Reprint requests to Dr. Hsiung at the Veterans Administration Hospital.)


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