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American Journal of Epidemiology Vol. 93, No. 4: 291-297
Copyright © 1971 by The Johns Hopkins University School of Hygiene and Public Health

other

NEUTRALIZING ANTIBODIES TO SV4O IN HUMAN SERA FROM SOUTH INDIA: SEARCH FOR ADDITIONAL HOSTS OF SV40

KEERTI V. SHAH, MANOHAR K. GOVERDHAN and HARVEY L. OZER1

1From the Department of Pathobiology, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland (Dr. Shah); Virus Research Center, Poona, India (Dr. Goverdhan); and Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014 (Dr. Ozer). The authors gratefully acknowledge the help of Dr. S. Krishnamurthi, and Dr. 8. Sankaran of the Cancer Institute, Madras; Dr. H. S. Bhat, Dr. Padam Singh, and Dr. P. Venugopal of the Christian Medical College and Hospital, Vellore, in collection of the human sera; Dr. T. R. Rao, Director, Virus Research Center, Poona, in providing the animal sera; and Dr. Fred Hymes, Immunoglobulin Reference Center, in providing the antiglobulin for RIP tests. Supported by Grant E440A from the American Cancer Society and by USPHS Grant 5 RO7 TW00141-09 CIC from NTH to The Johns Hopkins Center for Medical Research and Training.

Shah, K. V. (Johns Hopkins Univ. School of Hygiene and Public Health, Baltimore, Md. 21205), M. K. Goverdhan and H. L Ozer. Neutralizing antibodies to SV40 in human sera from South India: search for additional hosts of SV40. Amer J Epidem 93: 291–297, 1971.—Neutralizing antibodies to SV40 were detected in 10 of 155 sera of South Indian cancer patients. The donors lived several hundred miles outside the range of the rhesus monkey and gave no history of immunization against poliomyelitis. The protective sera had low neutralizing antibody tilers and did not stain viral or T antigen in fluorescent antibody tests. Radioisotope immunoprecipitation tests confirmed the results of some of the higher titered neutralization test positive human sera from North India. There was no serologic evidence that either of the two most prevalent South Indian monkeys, the bonnet macaque or the langur, was a natural host of SV40.

antibodies; monkeys; bonnet; langur; rhesus; simian virus 40; viruses


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