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American Journal of Epidemiology Vol. 91, No. 6: 593-600
Copyright © 1970 by The Johns Hopkins University School of Hygiene and Public Health

research-article

PERSISTENCE OF ANTIBODIES TO ST. LOUIS ENCEPHALITIS VIRUS IN SURVIVORS OF FLORIDA EPIDEMICS

JAMES O. BOND, Director1 and ARTHUR L. LEWIS2

1Epidemiology Research Center, Florida State Board of Health Tampa, Florida Present address, World Health Organization 1211 Geneva, Switzerland
2Epidemiology Research Center, Florida State Board of Health 4001 Tampa Bay Blvd., Tampa, Fla. 33614 (address for reprint requests)

Bond, J. O., and A. L Lewis, (Epidemiology Research Center, Florida State Board of Health, Tampa, Fla. 33614). Persistence of antibodies to St. Louis encephalitis virus in survivors of Florida epidemics. Amer. J. Epid., 1970, 97: 593–600.—The appearance, peak, decay and persistence of hemagglutination-inhibition (Ml), complement-fixing (CF), and serum neutralizing (NT) antibodies to SLE virus were studied in survivors of the 1959, 1961, and 1962 SLE epidemics in Florida. HI titers remained at a mean level of 1: 20 in two thirds of the survivors for at least eight years. CF antibody was detectable at the 1: 8 level in 30% by the fifth year of observation. Neutralizing antibody was present in all survivors tested at the five to eight year period. Sera stored four to five years, with repeated freezing and thawing, appeared to lose some specific HI and CF antibody when compared to earlier tests on fresh sera. The effects of storage on the stability of IgM and IgG immunoglobulins are briefly discussed in relation to the above findings. Until more is known on the effects of time, temperature, and method of storage on the immu-nologic activity of the various globulin classes, the results of studies on sera stored for long periods of time must be accepted with cautious interest.

antibody persistence; arbovirus; encephalitis; St. Louis; immunoglobulin stability


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