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American Journal of Epidemiology Vol. 91, No. 6: 585-592
Copyright © 1970 by The Johns Hopkins University School of Hygiene and Public Health

research-article

SEROEPIDEMIOLOGIC STUDIES OF CORONAVIRUS INFECTION IN ADULTS AND CHILDREN1

KENNETH MCINTOSH 2, ALBERT Z. KAPIKIAN, HORACE C. TURNER, JANET W. HARTLEY, ROBERT H. PARROTT3 and ROBERT M. CHANOCK

3Children's Hospital Washington, D.C.

Reprint requests to Dr. Chanock, Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Md. 20014

McIntosh, K. A. Z. Kapikian, H. C Turner, J. W. Hartley, R. H. Parrott and R. M. Chanock. (Lab. of Infectious Diseases, NIAID, NIH, Bethesda, Md. 20014) Sero-epidemiologic studies of coronavirus infection in adults and children. Amer. J. Epid., 1970, 97: 585–592-A seroepidemiologic study of infection by coronavirus strains 229E, OC38, OC43, and mouse hepatitis virus (MHV) strain A-59, is described. In adults with upper respiratory disease, two "outbreaks" of coronavirus infection occurred, one during the winter of 1965–1966 associated with complement fixing (CF) antibody responses to OC38, OC43 and MHV, and the other during the following winter associated with CF antibody responses to 229E. In hospitalized children, infection with 229E was rare; infection with OC38, OC43, and MHV occurred less often in hospitalized children with lower respiratory tract disease (3.5%) than in a control group with non-respiratory tract disease (8.2%). The limitations of the CF test using available coronavirus antigens are discussed.

antibodies; complement fixation tests; coronaviruses; respiratory tract diseases; serology; viruses

1From the National Institutes of Health, Public Health Service, National Institute of Allergy and Infectious Diseases and the National Cancer Institute, Laboratories of Infectious and Viral Diseases and the Viral Carcinogenesis Branch, Bethesda, Maryland.

2Present address: Department of Pediatrics, University of Colorado Medical Center, Denver, Colorado.


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