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American Journal of Epidemiology Vol. 91, No. 6: 575-584
Copyright © 1970 by The Johns Hopkins University School of Hygiene and Public Health

research-article

INFLUENZA ANTIBODY RESPONSE FOLLOWING AEROSAL ADMINISTRATION OF INACTIVATED VIRUIS1

R. H. WALDMAN, S. H. WOOD, E. J. TORRES and P. A. SMALL, JR.

Waldman, R, H., S. H. Wood, E. J. Torres, and P. A. Small, Jr. (Univ. of Florida College of Medicine, Gainesville, Ra. 3260). Influenza antibody response following aerosal administration of inactivated virus, Amer. J. Epid., 1970, 97: 575–584.—Several aspects of aerosol immunization with commercial bivalent influenza vaccine are reported in this study: 1) Duration of neutralizing antibody in sputum: after reaching peak levels of about 6 times the preimmunization level, the mean titer slowly fell to about twice the preimmunization level one year following immunization. 2) Response in patients with chronic lung disease: in 7 such patients the antibody response was just as good or better than normal volunteers and there were no adverse reactions to the aerosol immunization procedure. 3) Effect of particle size on antibody response: best serum antibody response resulted from small (1.5 µ) particle size; there was no great difference in sputum antibody response over a wide range of particle sizes (1–5–100 µ); and the best nasal antibody response resulted from large (40–100 µ) particles, or nose drops. Prior subcutaneous immunization did not improve the secretory antibody response resulting from subsequent 40 µ aerosol immunization. 4) Antibody response in children age 3–10: the nasal antibody response was of lesser magnitude in younger children (age 3–6), but essentially the same as that of adults in older children (age 7–10). 5) Immunoglobulin class of the influenza neutralizing antibody: serum antibody was IgG and secretory antibody was IgA.

antibodies; antigen-antibody reactions; immunization; aerosol; influenza vaccine

1From the Departments of Medicine and Microbiology, University of Florida College of Medicine, Gainesville, Fla. 32601.


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