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American Journal of Epidemiology Vol. 91, No. 6: 553-561
Copyright © 1970 by The Johns Hopkins University School of Hygiene and Public Health

research-article

EPIDEMIOLOGIC METHODS IN THE STUDY OF BLOOD PRESSURE IN RELATIVES OF TOXEMIC PRIMEPARAE1

WILLIAM C. SLOAN2, CHARLES DU V. FLOREY3, ROY M. ACHESON4 and DAVID M. KESSNER5

2Heart Disease Control Program, USPHS, on assignment to the Department of Epidemiology and Public Health, Yale University School of Medicine Present address: Department of Medicine, Mt. Sinai Hospital New York, N. Y.
3Department of Epidemiology and Public Health, Yale University School of Medicine Present address: Epidemiologies Research Unit, University of the West Indies Mona, Kingston 7, Jamaica, West Indies.
4Department of Epidemiology and Public Health, Yale University School of Medicine
5Departments of Epidemiology and Medicine, Yale University School of Medicine Present address: Board on Medicine, National Academy appliof Sciences 2101 Constitution Avenue, Washington, D.C, 20418.

Sloan, W. G, C du V. Florey, R. M. Acheson and D. M. Kessner (Board on Medicine, National Academy of Sciences, 2101 Constitution Ave., Wash., D.C 20418). Epidemiologic methods in the study of blood pressure in relatives of toxemic primiparae. Amer. J. Epid., 1970, 97; 553–561.—Five methods of analyzing blood pressure in first degree relatives of three index groups are presented and discussed. Examples of these different analytic approaches are illustrated using a small population of toxemic, non-toxemic and nulliparous index cases from a prospective study of toxemia. In these limited samples, none of the methods of analysis demonstrate a difference between the blood pressure of the relatives of primiparous toxemic and non-toxemic cases. The field and analytic methodology are discussed in light of the conflicting literature on this subject. The design and techniques of data analysis used in this preliminary investigation have been useful and would seem applicable to a more extensive evaluation of this controversial issue.

blood pressure; epidemiologic methods; epidemiology; pregnancy toxemias; toxemia

1From the department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Conn. This work was supported by grants from the United States Public Health Service (HD-01751 and FR-05443 and purchases orders D-222104-8 andD-278267-8).


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