American Journal of Epidemiology Vol. 91, No. 6: 531-538
Copyright © 1970 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
THE ASSOCIATION OF GENITAL HERPESVIRUS WITH CERVICAL ATYPIA AND CARCINOMA IN SITU1
Royston, I. and L. Aurelian (Dept. Laboratory Animal Medicine and Microbiology, Johns Hopkins Univ. School of Medicine, Baltimore, Md. 21205). The association of genital herpesvirus with cervical atypia and carcinoma in situ. Amer. J. Epid., 1970, 91: 531–538.—A neutralization test (multiplicity analysis) using an artificial mixture of two strains of herpes simplex virus, a prototype of the genital strain and a laboratory strain designated HSV-MP, was used to differentiate antibodies to the genital and facial strains (types 1 and 2) of herpes simplex virus in sera of patients with cervical neoplasia. The prevalence of antibody to the genital strain in women without cancer was found to increase both with increasing age and with decreasing socioeconomic class. The frequency of antibody among women with cervical neoplasia was uniformly high and thereby independent of age and socioeconomic class. Antibody was detected in 98% of 110 patients with cervical carcinoma at any stage of the disease, in 55% of the matched control women and 50% of those women with malignancies at sites other than the cervix. Statistically significant differences (p <.0005) were observed between antibodies to genital herpesvirus in patients with preinvasive carcinoma (atypia 95%t carcinoma in situ 100%) and a matched control population, differences which do not exist with regard to two other venereally transmitted diseases, trichomoniasis and syphilis. The data support the hypothesis that genital herpesvirus may be responsible for the induction of squamous neoplasia in the human cervix; however, further studies are required to determine whether the association is a causal one.
carcinoma; invasive; preinvasive; cervix neoplasms; herpes simplex virus; genital and facial strains; types 1 and 2; neoplasms; syphilis; trichomonas
2Recipient of a Ford Foundation Fellowship in Reproductive Biology. This investigation was supported by U.S. Public Health Service grant (Fit. 00130) and by grant 1N-11K from the American Cancer Society. The authors are indebted to Dr. Hugh. J. Davis for invaluable advice and criticism, and to Mrs. Y. Stein for capable technical assistance
1From the Departments of Microbiology and Laboratory Animal Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  L. COREY, K. H. FIFE, J. K. BENEDETTI, C. A. WINTER, A. FAHNLANDER, J. D. CONNOR, M. A. HINTZ, and K. K. HOLMES Intravenous Acyclovir for the Treatment of Primary Genital Herpes Ann Intern Med, June 1, 1983; 98(6): 914 - 921. [Abstract] [PDF]
|
|
|
|
 |
|
 L. Aurelian, B. Schumann, R. L. Marcus, and H. J. Davis Antibody to HSV-2 Induced Tumor Specific Antigens in Serums from Patients with Cervical Carcinoma Science, July 13, 1973; 181(4095): 161 - 164. [Abstract] [PDF]
|
|
|
|
|
|
Y. M. Centifanto, D. M. Drylie, S. L. Deardourff, and H. E. Kaufman Herpesvirus Type 2 in the Male Genitourinary Tract Science, October 20, 1972; 178(4058): 318 - 319. [Abstract] [PDF]
|
|
|
|
|
|
L. Aurelian, J. D. Strandberg, L. V. Melendez, and L. A. Johnson Herpesvirus Type 2 Isolated from Cervical Tumor Cells Grown in Tissue Culture Science, November 12, 1971; 174(4010): 704 - 707. [Abstract] [PDF]
|
|