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American Journal of Epidemiology Vol. 91, No. 4: 418-429
Copyright © 1970 by The Johns Hopkins University School of Hygiene and Public Health

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NOTES ON THE EFFECT OF MEASLES AND MEASLES VACCINE IN A VIRGIN-SOIL POPULATION OF SOUTH AMERICAN INDIANS1

JAMES V. NEEL2, WILLARD R. CENTERWALIA3,4, NAPOLEON A. CHAGNON5 and HELEN L. CASEY5

2Department of Human Genetics, University of Michigan Medical School Ann Arbor, Mich. 48104
3Fellow, University of Michigan School of Public Health
5National Communicable Disease Center Atlanta, Ga. 30333

4Present address: Department of Pediatrics and Division of Maternal and Child Health, Schools of Medicine and Public Health, Loma Linda University, Loma Linda, Calif

Noel, J. V. (Dept. Human Genetics, Univ. of Michigan Medical School, Ann Arbor, Mich. 48104), W. R. Centerwall, N. A. Chagnon and H. L Casey. Notes on the effect of measles and measles vaccine in a virgin-soil population of South American Indians. Amer. J. Epid., 1970, 91: 418–429.—Serologic studies conducted on 606 blood specimens obtained during expeditions in 1966 and 1967 to the primitive Yanomama Indians of Southern Venezuela and Northern Brazil revealed these Indians to be essentially a "virgin-soil" population for measles. Accordingly, measles vaccine was obtained for administration during an expedition in 1968. Measles itself was introduced to the Indians coincidental with the arrival of the expedition in the field. Observations are recorded on the effect of Edmonston B vaccine administered both with and without MIG in standard doses, as well as on the response to the disease itself. Although the circumstances surrounding the epidemic were such that the observations were fragmentary, we think the response of these probably previously unexposed Indians to measles virus is only slightly greater than that of the members of long-civilized Caucasian populations. This greater response may well be due to factors other than an increased genetic susceptibility.

epidemiology; Indians, South America; measles, vaccination, virus

1The observations reported herein were made in the course of a collaborative study involving members of the University of Michigan and the Veneauelan Institute of Scientific Investigation, financed in part by grant AT(11-1)-1552 from the U. S. Atomic Energy Commission.


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