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American Journal of Epidemiology Vol. 87, No. 3: 633-642
Copyright © 1968 by The Johns Hopkins University School of Hygiene and Public Health

research-article

CONCURRENT ADMINISTRATION OF LIVE ADENOVIRUS, TYPE 4 AND LIVE POLIOVIRUS, TYPE 1 VACCINES1

JAMES CHIN, EDWIN H. LENNETTE, JACK H. SCHIEBLE and ROBERT L. MAGOFFIN

Chin, James, E. H. Lennette, J. H. Schieble and R. L. Magoffin (215) Berkeley Way, Berkeley, Calif. 94704). Concurrent administration of live adenovirus, type 4, and live poliovirus, Type 1 Vaccines. Amer. L Epid., 1968, 87: 633–642.—A study was conducted in a recruit company at Fort Ord, California in late 1965 to determine whether live poliovirus, type 1 vaccine and live adenovirus, type 4 vaccine would interfere with one another when given simultaneously. The pattern of response obtained to the adenovirus vaccine with or without poliovirus vaccine was in close agreement with results of other published studies on the adenovirus vaccine. The only finding suggestive of some interference between the two vaccines was the apparent absence of poliovirus from any of the throat swab specimens of recruits who received both vaccines. No significant interference was observed with respect to rectal excretion of, and serologic response to, the vaccine viruses.

1 From the Viral and Rickettaial Disease Laboratory, California State Department of Public Health, Berkeley, 94704. This investigation was conducted under the auspices of the Commission on Influenza, Armed Forces Epidemiological Board and supported in part by the U. S. Army Medical Research and Development Command, Department of the Army (Contract number DA-49-007-MD-950) and in part by the Vaccine Development Branch, National Institute of Allergy and LnfefctiouB Diseases, United States- Public Health Service (Contract number PH-43-63-L141). We wish to thank Dr. John Bolton and Major Richard Park, MC, UJ3.A. for assistance n collecting throat swab specimens for this rtudy, and Mrs. Helen Ho and Mibs Virginia Fox for technical assistance in the laboratory.


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