American Journal of Epidemiology Vol. 87, No. 3: 592-598
Copyright © 1968 by The Johns Hopkins University School of Hygiene and Public Health
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STUDIES ON THE PERSISTENCE OF MALARIAL ANTIBODY RESPONSE
2Laboratory of Parasite Chemotherapy, National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, Maryland, 20014
Collins, William E (P.O. Box 80190, Chamblee, Ga. 30005), J. C Skinner and G. M. Jeffery. Studies on the persistence of malarial antibody response. Amer. J. Epid., 1968, 87: 592–598.—Sera from 95 patients having had induced infections with P. falciparum, P. malariae, P. vivox or P. ovale were tested for presence of specific antibody using the indirect fluorescent antibody method. The intervals between termination of the infections and acquisition of the sera ranged from approximately 6 months to 26 years. Specific serum dilution end-points high enough to be considered positive (1: 20 or greater) were found as late as 8 years after termination of a P. faldparum infection and 13 years after termination of P. malariae. For P. vivax, positive responses could not be found three years after termination of the infection. Where patients had experienced multiple infections with malaria, positive responses were seen after even longer periods subsequent to termination of the infections. In general, for all sera tested, the median response decreased sharply when three years had elapsed after termination of the infections and continued to decrease with time thereafter.
With patients who had experienced P. malariae infections which had not been terminated by curative antimalarial treatment, sera collected 15 to 24 years after the last known patent parasitemia frequently yielded a positive FA response.
1Section on Primate Malaria, Laboratory of Parasite Chemotherapy, National Institute of Allergy and Infectious Diseases, P.O. Box 80190, Chamblee, Georgia 30005. The authors wish to thank the staff of the Palmetto State Hospital, particularly the late Dr. Sol McLendon, without whose cooperation and assistance these studies could not have been done. We also wish to acknowledge the technical assistance of Mr. Andrew J. Harrison, Mr. Thomas S. Kearse and Miss Elizabeth G. Guinn in the collection and processing of the specimens.
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