American Journal of Epidemiology Vol. 87, No. 3: 539-550
Copyright © 1968 by The Johns Hopkins University School of Hygiene and Public Health
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COMPARISON OF TWO LOTS OF IMMUNE SERUM GLOBULIN FOR PROPHYLAXIS OF INFECTIOUS HEPATITIS1
2Epidemiology and Research Analysis Section, Foreign Quarantine Program, N.CD.C. Formerly Chief, Viral Diseases Section, Epidemiology Program, N.C.D.C.
3Barnes Hospital, St. Louis, Missouri. Formerly Epidemic Intelligence Service Officer Epidemiology Program, N.CD.C, Ramlah, Israel
4Ministry of Health, State of Israel, and Principal Investigator, Hepatitis Project Jerusalem, Israel
5-Division - of -Epidemiology, Ministry of Health, Jerusalem, Israel. Formerly Epidemiologist, Hepatitis Project Ramlah, Israel
6Central Public Health District, Ministry of Health Ramlah, Israel
Requests for reprints should be addressed to Dr. Mosley at the National Communicable Disease Center.
Mosley, J. W. (N.GD.G, Atlanta, Ga. 30333), D. M. Reisler, D. Brachott, D. Roth and J. Weiser. Comparison of 2 lots of immune serum globulin for prophylaxis of infectious hepatitis. Amer. J. Epid., 1968, 87: 539–550.—Two lots of immune serum globulin which differed in several respects were compared for potency against infectious hepatitis. Their efficiencies for protection of exposed household contacts were 47 and 87 percent, respectively. This disparity is probably attributable, in large part, to differences in antibody concentrations and/or the fact that one preparation had undergone fragmentation into more rapidly excreted components.
1 From the Hepatitis Project, Ministry of Health, State of Israel; and the National Communicable Disease Center, Bureau of Disease Prevention and Environmental Control, U. S. Public Health Service, Atlanta, Georgia 30333. (Requests for reprints should be addressed to Dr. Mosley at the National Communicable Disease Center.) The investigators are indebted to personnel of the Central Public Health District for their cooperation and participation in this study.
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