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American Journal of Epidemiology Vol. 87, No. 3: 520-529
Copyright © 1968 by The Johns Hopkins University School of Hygiene and Public Health

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CHRONIC DISEASE IN FORMER COLLEGE STUDENTS. VII. EARLY PRECURSORS OF NONFATAL CORONARY HEART DISEASE1

MELVYN C. THORNE, ALVIN L. WING and RALPH S. PAFFENBARGER, JR.

Thorne, Melvyn C., Alvin L. Wing and Ralph S. Paffenbarger, Jr. (Natl. Heart Inst. and Harvard Univ. School of Public Health, Boston, Mass., 02115) Chronic disease in former college students. VII. Early precursors of nonfatal coronary heart disease. Amer. J. Epid., 1968, 87: 520–529.—In a continuing study of former students from Harvard and the University of Pennsylvania, the frequency of doctor-diagnosed coronary heart disease was determined by self-assessed questionnaire in 1962. An 80 per cent response was achieved, and the validity of response was measured by case-taking of a small stratified sample of former students living in the Boston or Philadelphia area. Findings here are limited to former University of Pennsylvania male students who were less than thirty years of age of college case-taking, 1931–1940, and who returned a questionnaire, 1962. A total of 213 doctor-diagnosed cases of coronary heart disease was identified among the 7, 685 questionnaire respondents meeting these criteria. By reviewing college health and other records, five characterisitics in youth were found associated with the later development of nonfatal coronary heart disease. These were cigarette smoking, higher levels of systolic and diastolic blood pressure, increased ponderosity, shorter body stature, and less participation in exercise and sports. When considered in paired combinations, the characteristics further increased the risk of coronary morbidity.

1 From the Field Epidemiological Research Section, National Heart Institute, U. S. Public Health Service and the Department of Epidemiology, Harvard University School of Public Health. Address reprint requests to Dr. Paffenbarger at 1 Shattuck Street, Boston, Mass. 02115.


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