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American Journal of Epidemiology Advance Access originally published online on September 15, 2009
American Journal of Epidemiology 2009 170(8):948-956; doi:10.1093/aje/kwp236
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American Journal of Epidemiology © The Author 2009. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

Tumor Necrosis Factor Polymorphisms and Alcoholic Liver Disease: A HuGE Review and Meta-Analysis

Miguel Marcos, Mercedes Gómez-Munuera, Isabel Pastor, Rogelio González-Sarmiento and Francisco-Javier Laso

Correspondence to Dr. Miguel Marcos, Servicio de Medicina Interna II, Hospital Universitario de Salamanca, Paseo de San Vicente 58-182, 37007 Salamanca, Spain (e-mail: migmarmar10{at}hotmail.com).

Received for publication November 10, 2008. Accepted for publication July 8, 2009.

The association between alcoholic liver disease (ALD) and tumor necrosis factor-{alpha} gene (TNFA) polymorphisms has been analyzed in several studies, but results have been conflicting. The main purpose of this study was to integrate previous findings and explore whether these polymorphisms are associated with susceptibility to ALD. The authors surveyed studies on the relation between TNFA gene polymorphisms and ALD by means of an electronic database search. A meta-analysis was conducted in a random-effects model. The association between ALD and the –238G>A or –308G>A polymorphism of the TNFA gene has been analyzed in 11 studies. Concerning the –238G>A polymorphism, the authors found a significant association between possession of the A allele and risk of alcoholic liver cirrhosis (odds ratio = 1.47, 95% confidence interval: 1.05, 2.07). Meta-analysis of the relation between the –308G>A polymorphism and ALD did not show any significant association. Given the limited number of studies and the potential biases, more data are needed to confirm the association described for the –238A allele.

epidemiology; genetics; genome, human; liver cirrhosis, alcoholic; liver diseases, alcoholic; meta-analysis; review; tumor necrosis factor-alpha

Abbreviations: ALD, alcoholic liver disease; HWE, Hardy-Weinberg equilibrium; TNF, tumor necrosis factor; TNFA, TNF-{alpha} gene

Editor's note: This article also appears on the Web site of the Human Genome Epidemiology Network (http://www.hugenet.org.uk/index.html).


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