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American Journal of Epidemiology Advance Access originally published online on August 11, 2009
American Journal of Epidemiology 2009 170(6):703-707; doi:10.1093/aje/kwp221
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American Journal of Epidemiology Published by the Johns Hopkins Bloomberg School of Public Health 2009.

Invited Commentary

Invited Commentary: Genes, Environment, and Hybrid Vigor

Marta Gwinn, Idris Guessous and Muin J. Khoury

Correspondence to Dr. Marta Gwinn, Office of Public Health Genomics, Centers for Disease Control and Prevention, 4770 Buford Highway, Mailstop K-89, Atlanta, GA 30341 (e-mail: mgwinn{at}cdc.gov).

Received for publication March 6, 2009. Accepted for publication May 11, 2009.

In the 1950s, case-control studies of smoking and lung cancer established a paradigm for epidemiologic studies of risk factors for chronic diseases. Since then, thousands of case-control studies have examined possible associations of countless risk factors with numerous diseases, rarely finding associations as strong or consistent as that of smoking with lung cancer. Recently, researchers have applied advances in molecular genetics to conduct candidate gene and genome-wide association studies of lung cancer. Skeptics among both epidemiologists and geneticists have argued that genomic research adds little value when most cases of disease can be attributed to a preventable exposure; however, well-conducted studies of gene-environment interactions that draw on data from more than 50 years of research in toxicology, pathophysiology, and behavioral science offer important models for the development of more comprehensive approaches to understanding the etiology of chronic diseases.

case-control studies; DNA damage; DNA repair; genetic predisposition to disease; lung neoplasms; oxoguanine glycosylase 1, human; smoking

Abbreviations: hOGG1, human 8-oxoguanine DNA N-glycosylase 1; HuGE, human genome epidemiology


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Related articles in Am. J. Epidemiol.:

Interactive Effect of Cigarette Smoking With Human 8-Oxoguanine DNA N-Glycosylase 1 (hOGG1) Polymorphisms on the Risk of Lung Cancer: A Case-Control Study in Taiwan
Chin-Hao Chang, Chin-Fu Hsiao, Gee-Chen Chang, Ying-Huang Tsai, Yuh-Min Chen, Ming-Shyan Huang, Wu-Chou Su, Wan-Shan Hsieh, Pan-Chyr Yang, Chien-Jen Chen, and Chao A. Hsiung
Am. J. Epidemiol. 2009 170: 695-702. [Abstract] [Full Text]  



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C. Carlsten and W. Burke
RE: "INVITED COMMENTARY: GENES, ENVIRONMENT, AND HYBRID VIGOR"
Am. J. Epidemiol., January 1, 2010; 171(1): 133 - 133.
[Full Text] [PDF]


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