American Journal of Epidemiology Advance Access originally published online on August 11, 2009
American Journal of Epidemiology 2009 170(6):695-702; doi:10.1093/aje/kwp019
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ORIGINAL CONTRIBUTIONS |
Interactive Effect of Cigarette Smoking With Human 8-Oxoguanine DNA N-Glycosylase 1 (hOGG1) Polymorphisms on the Risk of Lung Cancer: A Case-Control Study in Taiwan
Correspondence to Dr. Chao A. Hsiung, Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, 35, Keyan Road, Zhunan, Miaoli 350, Taiwan, Republic of China (e-mail: hsiung{at}nhri.org.tw).
Received for publication April 14, 2008. Accepted for publication January 9, 2009.
Human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) plays an important role in repairing oxidative DNA damage induced by tobacco carcinogens. In this case-control study, the authors examined the interactive effect of hOGG1 gene polymorphisms and cigarette smoking on the risk of lung cancer in Taiwan. A total of 1,096 cases and 1,007 controls were enrolled from 6 medical centers in Taiwan during 2002–2004. hOGG1 Ser326Cys genetic polymorphisms were determined using the MassARRAY system (SEQUENOM, Inc., San Diego, California). Tobacco smoking history was obtained through personal interview according to a structured questionnaire. Logistic regression analysis was used to estimate multivariate-adjusted odds ratios and 95% confidence intervals. The odds of developing lung cancer for persons with the Cys/Cys genotype versus the Ser/Ser genotype were 1.11 (95% confidence interval (CI): 0.74, 1.65) for never smokers, 1.45 (95% CI: 0.74, 2.83) for moderate smokers, and 3.52 (95% CI: 1.54, 8.06) for heavy smokers. The P value for interaction in the logistic model was 0.01. The increased risk associated with the Cys/Cys genotype among heavy smokers remained statistically significant for various histologic types of lung cancer, including adenocarcinoma, squamous cell carcinoma, and small cell carcinoma. The authors conclude that there was a noticeable modifying effect on the association between hOGG1 genotype and lung cancer risk by cigarette smoking status.
case-control studies; DNA damage; DNA repair; genetic predisposition to disease; lung neoplasms; oxoguanine glycosylase 1, human; smoking
Abbreviations: CI, confidence interval; hOGG1, human 8-oxoguanine DNA N-glycosylase 1; OR, odds ratio
Editor's note: An invited commentary on this article appears on page 703.
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