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American Journal of Epidemiology Advance Access originally published online on July 13, 2009
American Journal of Epidemiology 2009 170(4):464-471; doi:10.1093/aje/kwp156
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American Journal of Epidemiology © The Author 2009. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

ORIGINAL CONTRIBUTIONS

Vitamin C Deficiency in a Population of Young Canadian Adults

Leah Cahill, Paul N. Corey and Ahmed El-Sohemy

Correspondence to Dr. Ahmed El-Sohemy, Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, FitzGerald Building, Room 350, 150 College Street, Toronto, Ontario M5S 3E2, Canada (e-mail: a.el.sohemy{at}utoronto.ca).

Received for publication March 17, 2009. Accepted for publication May 11, 2009.

A cross-sectional study of the 979 nonsmoking women and men aged 20–29 years who participated in the Toronto Nutrigenomics and Health Study from 2004 to 2008 was conducted to determine the prevalence of serum ascorbic acid (vitamin C) deficiency and its association with markers of chronic disease in a population of young Canadian adults. High performance liquid chromatography was used to determine serum ascorbic acid concentrations from overnight fasting blood samples. A 1-month, 196-item food frequency questionnaire was used to assess dietary intakes. Results showed that 53% of subjects had adequate, 33% had suboptimal, and 14% had deficient levels of serum ascorbic acid. Subjects with deficiency had significantly higher measurements of mean C-reactive protein, waist circumference, body mass index, and blood pressure than did subjects with adequate levels of serum ascorbic acid. The odds ratio for serum ascorbic acid deficiency was 3.43 (95% confidence interval: 2.14, 5.50) for subjects who reported not meeting the recommended daily intake of vitamin C compared with those who did. Results suggest that 1 of 7 young adults has serum ascorbic acid deficiency, in part, because of unmet recommended dietary intakes. Furthermore, serum ascorbic acid deficiency is associated with elevated markers of chronic disease in this population of young adults, which may have long-term adverse health consequences.

ascorbic acid; biological markers; chronic disease; ethnic groups; scurvy

Abbreviations: RDA, recommended dietary allowance


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 Am J EpidemiolHome page
L. J. Hoffer
Re: "Vitamin C Deficiency in a Population of Young Canadian Adults"
Am. J. Epidemiol., February 1, 2010; 171(3): 387 - 387.
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 Am J EpidemiolHome page
L. Cahill, P. Corey, and A. El-Sohemy
The Authors Reply
Am. J. Epidemiol., February 1, 2010; 171(3): 387 - 388.
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 Am. J. Clin. Nutr.Home page
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Functional genetic variants of glutathione S-transferase protect against serum ascorbic acid deficiency
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