Skip Navigation


American Journal of Epidemiology Advance Access originally published online on May 22, 2009
American Journal of Epidemiology 2009 170(2):193-202; doi:10.1093/aje/kwp108
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
170/2/193    most recent
kwp108v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Endeshaw, Y. W.
Right arrow Articles by Bliwise, D. L.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Endeshaw, Y. W.
Right arrow Articles by Bliwise, D. L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology © The Author 2009. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

ORIGINAL CONTRIBUTIONS

Sleep-disordered Breathing and Frailty in the Cardiovascular Health Study Cohort

Yohannes W. Endeshaw, Mark L. Unruh, Michael Kutner, Anne B. Newman and Donald L. Bliwise

Correspondence to Dr. Yohannes W. Endeshaw, Division of Geriatrics and Gerontology, Department of Medicine, Emory University School of Medicine, 1841 Clifton Road NE, No. 535, Atlanta, GA 30329 (e-mail: yendesh{at}emory.edu).

Received for publication January 2, 2009. Accepted for publication April 8, 2009.

Sleep-disordered breathing (SDB) is associated with pathophysiology that may influence the development and progression of frailty. Using data collected in 1995–1996, the authors explored the relation between SDB and components of frailty among 1,042 participants of the Cardiovascular Health Study. Diagnosis of SDB was based on the results of overnight polysomnography, and severe SDB was defined as an apnea-hypopnea index of >30 per hour of sleep. Slow walking speed, low grip strength, exhaustion, low physical activity, and unexplained weight loss were referred to as frailty indicator variables. There were 584 (56%) female and 458 (44%) male participants, and the mean age was 77 (standard deviation, 4) years. There was independent association between severe SDB and 1 or more frailty indicator variables (adjusted odds ratio = 4.85, 95% confidence interval: 1.40, 16.78), slow walking speed (adjusted odds ratio = 2.67, 95% confidence interval: 1.04, 6.84), and low grip strength (adjusted odds ratio = 3.29, 95% confidence interval: 1.36, 7.96) among female study participants. The finding of an independent association between SDB and frailty indicator variables among older women could have important implications in interventions aimed at preventing or delaying the progression of frailty.

frailty; hand strength; mobility limitation; muscle strength; sleep apnea syndromes; weight loss

Abbreviations: SDB, sleep-disordered breathing


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.