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American Journal of Epidemiology Advance Access originally published online on March 18, 2009
American Journal of Epidemiology 2009 169(9):1064-1069; doi:10.1093/aje/kwp033
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American Journal of Epidemiology © The Author 2009. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

ORIGINAL CONTRIBUTIONS

Plasma Urate and Parkinson's Disease in the Atherosclerosis Risk in Communities (ARIC) Study

Honglei Chen, Thomas H. Mosley, Alvaro Alonso and Xuemei Huang

Correspondence to Dr. Honglei Chen, Epidemiology Branch, National Institute of Environmental Health Sciences, 111 T. W. Alexander Drive, PO Box 12233, Mail Drop A3-05, Research Triangle Park, NC 27709 (e-mail: chenh2{at}niehs.nih.gov).

Received for publication October 22, 2008. Accepted for publication January 26, 2009.

Higher plasma urate concentration has been linked to lower risk of Parkinson's disease in men, but data are lacking on women and African Americans. The authors examined plasma urate in relation to Parkinson's disease in the biracial, population-based Atherosclerosis Risk in Communities (ARIC) cohort. Between 1987 and 1989, 15,792 participants, aged 45–64 years, were recruited from 4 US communities and have since been followed with 3 triennial visits and annual surveillance. Plasma urate was measured at visits 1 and 2, and the concentrations were highly correlated. From visit 1 through 2004, 95 potential cases of Parkinson's disease were identified from multiple sources. Odds ratios and 95% confidence intervals were calculated from multivariate logistic regression models. Plasma urate concentration was inversely associated with Parkinson's disease occurrence. The odds ratios between extreme quartiles of plasma urate were 0.4 (95% confidence interval: 0.2, 0.8) in the overall analysis, 0.3 (95% confidence interval: 0.1, 0.7) for men, and 0.4 (95% confidence interval: 0.2, 1.0) for Caucasians. Such an association was also suggested among women and African Americans but was not statistically significant because of small sample sizes. These data support the previous finding that urate may be a protective factor against Parkinson's disease.

cohort studies; Parkinson disease; uric acid

Abbreviations: ARIC, Atherosclerosis Risk in Communities; ICD, International Classification of Diseases


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