Skip Navigation


American Journal of Epidemiology Advance Access originally published online on February 18, 2009
American Journal of Epidemiology 2009 169(8):954-961; doi:10.1093/aje/kwn421
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
169/8/954    most recent
kwn421v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Wilson, K. M.
Right arrow Articles by Willett, W. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wilson, K. M.
Right arrow Articles by Willett, W. C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology © The Author 2009. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

ORIGINAL CONTRIBUTIONS

Dietary Acrylamide Intake and Risk of Premenopausal Breast Cancer

Kathryn M. Wilson, Lorelei A. Mucci, Eunyoung Cho, David J. Hunter, Wendy Y. Chen and Walter C. Willett

Correspondence to Dr. Kathryn M. Wilson, Channing Laboratory, Brigham and Women's Hospital, 181 Longwood Avenue, Third Floor, Boston, MA 02115 (e-mail: kwilson{at}hsph.harvard.edu).

Received for publication July 29, 2008. Accepted for publication December 22, 2008.

Acrylamide, a probable human carcinogen, is formed during high-temperature cooking of many commonly consumed foods. It is widespread; approximately 30% of calories consumed in the United States are from foods containing acrylamide. In animal studies, acrylamide causes mammary tumors, but it is unknown whether the level of acrylamide in foods affects human breast cancer risk. The authors studied the association between acrylamide intake and breast cancer risk among 90,628 premenopausal women in the Nurses' Health Study II. They calculated acrylamide intake from food frequency questionnaires in 1991, 1995, 1999, and 2003. From 1991 through 2005, they documented 1,179 cases of invasive breast cancer. They used Cox proportional hazards models to assess the association between acrylamide and breast cancer risk. The multivariable-adjusted relative risk of premenopausal breast cancer was 0.92 (95% confidence interval: 0.76, 1.11) for the highest versus the lowest quintile of acrylamide intake (Ptrend = 0.61). Results were similar regardless of smoking status or estrogen and progesterone receptor status of the tumors. The authors found no associations between intakes of foods high in acrylamide, including French fries, coffee, cereal, potato chips, potatoes, and baked goods, and breast cancer risk. They found no evidence that acrylamide intake, within the range of US diets, is associated with increased risk of premenopausal breast cancer.

acrylamide; breast neoplasms; diet

Abbreviations: CI, confidence interval; ER, estrogen receptor; FFQ, food frequency questionnaire; PR, progesterone receptor; RR, relative risk


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 JNCI J Natl Cancer InstHome page
L. A. Mucci and H.-O. Adami
The Plight of the Potato: Is Dietary Acrylamide a Risk Factor for Human Cancer?
J Natl Cancer Inst, May 6, 2009; 101(9): 618 - 621.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.