American Journal of Epidemiology Advance Access originally published online on February 24, 2009
American Journal of Epidemiology 2009 169(8):937-945; doi:10.1093/aje/kwp003
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ORIGINAL CONTRIBUTIONS |
Association of Diabetes With Prostate Cancer Risk in the Multiethnic Cohort
Correspondence to Dr. Christopher A. Haiman, Harlyne Norris Research Tower, 1450 Biggy Street, Room 1504A, Mail Code LG591 MC9601, Los Angeles, CA 90033 (e-mail: haiman{at}usc.edu).
Received for publication August 25, 2008. Accepted for publication January 6, 2009.
Among men of European ancestry, diabetics have a lower risk of prostate cancer than do nondiabetics. The biologic basis of this association is unknown. The authors have examined whether the association is robust across populations in a population-based prospective study. The analysis included 5,941 prostate cancer cases identified over a 12-year period (1993–2005) among 86,303 European-American, African-American, Latino, Japanese-American, and Native Hawaiian men from the Multiethnic Cohort. The association between diabetes and prostate-specific antigen (PSA) levels (n = 2,874) and PSA screening frequencies (n = 46,970) was also examined. Diabetics had significantly lower risk of prostate cancer than did nondiabetics (relative risk = 0.81, 95% confidence interval (CI): 0.74, 0.87; P < 0.001), with relative risks ranging from 0.65 (95% CI: 0.50, 0.84; P = 0.001) among European Americans to 0.89 (95% CI: 0.77, 1.03; P = 0.13) among African Americans. Mean PSA levels were significantly lower in diabetics than in nondiabetics (mean PSA levels, 1.07 and 1.28, respectively; P = 0.003) as were PSA screening frequencies (44.7% vs. 48.6%; P < 0.001); however, this difference could explain only a small portion (
20%) of the inverse association between these diseases. Diabetes is a protective factor for prostate cancer across populations, suggesting shared risk factors that influence a common mechanism.
cohort studies; diabetes mellitus, type 2; ethnology; prostate-specific antigen; prostatic neoplasms
Abbreviations: CI, confidence interval; PSA, prostate-specific antigen; RR, relative risk
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  I. G. Jeong, S. S. Hwang, H. K. Kim, H. Ahn, and C.-S. Kim The Association of Metabolic Syndrome and Its Components with Serum Prostate-Specific Antigen Levels in a Korean-Screened Population Cancer Epidemiol. Biomarkers Prev., February 1, 2010; 19(2): 371 - 380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Jayachandran, W. J. Aronson, M. K. Terris, J. C. Presti Jr., C. L. Amling, C. J. Kane, and S. J. Freedland Diabetes and Outcomes After Radical Prostatectomy: Are Results Affected by Obesity and Race? Results from the Shared Equal-Access Regional Cancer Hospital Database Cancer Epidemiol. Biomarkers Prev., January 1, 2010; 19(1): 9 - 17. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Y. Hernandez, S.-Y. Park, L. R. Wilkens, B. E. Henderson, and L. N. Kolonel Relationship of Body Mass, Height, and Weight Gain to Prostate Cancer Risk in the Multiethnic Cohort Cancer Epidemiol. Biomarkers Prev., September 1, 2009; 18(9): 2413 - 2421. [Abstract] [Full Text] [PDF]
|
|